Fully-Automated
Lab-on-a-Chip Technology

How It Works

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Giant Magnetoresistance (GMR) Working Principles

The electrical resistance of a metallic structure with several nanometers non-magnetic conducting thin film (e.g. copper) sandwiched between two ferromagnetic layers changes depending on the relative magnetization direction of the ferromagnetic layers.

Parallel magnetization results in lower resistance, while anti-parallel magnetization results in higher resistance. This phenomenon facilitates detection of stray fields from magnetic materials at nanometer scales.

A bead with magnetic nanoparticles added to a standard assay changes the local magnetization of a ferromagnetic layer in the GMR structure, which can be detected as a small change in resistance.

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Bio-Surface And Magnetic Nanoparticles Bead Integration

 

Zepto Life’s on-chip bio-surface technology holds the capture antibodies in place. The bio-surface on the nanomagnetic particles allows them to be pre-labeled with detection antibodies. Analyte biomarkers are sandwich and specifically bound by capture and detection antibodies. Nanomagnetic particles would be attracted onto sensor surface and signal is read out real-time. Each biosensor is dedicated to a single biomarker.

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Multiplex and Scalable

The multiple biosensors on a biochip is designed to deliver clinical results of a central laboratory at a point-of-care setting.
Each biochip is able to simultaneously detect and quantify multiple biomarkers.

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Fully-Automated Assay

The disposable test cartridge uses microfluidics and on-chip bio-surface technologies to detect target antigens or antibodies from the microliter blood sample and immunoassay. The small channels are designed to decrease the assay time and increase assay automation.

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